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. 2014 Jul 28;9(7):e102535. doi: 10.1371/journal.pone.0102535

Figure 1. Resveratrol inhibits BCSCs in vitro.

Figure 1

(A) The cytotoxic effects of resveratrol treatment (0, 10, 20 and 40 µM) for 24 h on breast epithelial cells MCF10A and breast cancer cells SUM159, MCF-7, detected by CCK-8 assay. (B) The cytotoxic effects of resveratrol treatment for 24 h on BCSCs isolated from SUM159 and MCF-7 cells. (C) Treatment with resveratrol for 24 h significantly decreased the percentage of ALDH-positive population in SUM159 cells. The changing situations in MCF-7 were alike. (D) The effect of resveratrol treatment for 7 days on the formation of mammospheres in BCSCs. Data are presented as mean ± SD (n = 3). * P<0.05, ** P<0.01 compared with the control (0 µM).