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. Author manuscript; available in PMC: 2014 Jul 28.
Published in final edited form as: Adv Tech Biol Med. 2013 Jun;1(1):103. doi: 10.4172/atbm.1000103

Table 1.

Examples of plant-derived pharmaceutical proteins produced via agroinfiltration.

Plant Host Pharmaceutical Target Development Stage References
N. benthamiana Influenza A H5N1 HA VLP vaccine Phase I/II clinical trial [39,40]
N. benthamiana Influenza A H1N1 HA VLP vaccine Phase I [41]
N. benthamiana Ebola immune-complex vaccine Preclinical [29]
N. benthamiana HBcAg non-enveloped VLP vaccine Preclinical [20]
N. benthamiana HBsAg enveloped VLP vaccine Preclinical [4]
N. benthamiana HIV-1 Pr55gag vaccine Preclinical [4]
N. benthamiana WNV prM/M and E vaccine Preclinical [4,12]
N. benthamiana, Lettuce Ebola therapeutics based on mAb Preclinical [21,28,34,42]
N. benthamiana, Lettuce Norovirus NVCP VLP vaccine Preclinical [18,20,34]
N. benthamiana, Lettuce WNV therapeutics based on mAb Preclinical [6,34]
N. benthamiana, Lettuce WNV DIII vaccine Preclinical [12,34]

HA: hemagglutinin; VLP: virus-like particle; HBcAg: hepatitis B core antigen; HBsAg: hepatitis B surface antigen; HIV: human immunodeficiency retrovirus; Pr55gag: major core protein Gag precursor; WNV: West Nile virus; PreM/M: premembrane and membrane protein; E: envelope protein; mAb: monoclonal antibody; NVCP: Norwalk virus capsid protein; DIII: domain III of envelope protein.