Table 1.
Parameter | Unit | Bup IR | Bup SR Lab | ||||
Dose | mg/kg | 0.03 | 0.05 | 0.1 | 2 | 0.3 | 1.2 |
AUClast | h × ng/mL | 2.2 ± 0.6 | 5.6 ± 2.7 | 19.1 ± 5.0 | 82.0 ± 18.2 | 20.1 ± 5.7 | 62.9 ± 11.6 |
Tmax | h | 1 | 1 | 3 | 1 | 6 | 0.5 |
Cmax | ng/mL | 0.5 ± 0.4 | 0.5 ± 0.4 | 1.3 ± 1.4 | 20.2 ± 11.9 | 0.8 ± 0.7 | 5.0 ± 2.3 |