. 2014 Jul;53(4):399–403.

Table 1.

Effects of 21-day oral administration of pazufloxacin, meloxicam, and their combination on various markers of oxidative status (mean ± SE; n = 4) in rabbit blood

	Untreated controls	Pazufloxacin	Meloxicam	Pazufloxacin + meloxicam
Reduced glutathione (nmol/mL)
Day 0	431.43 ± 20.58^a	431.43 ± 23.88^a	490.43 ± 24.50^a	421.29 ± 5.71^a
Day 7	464.62 ± 41.74^a	555.88 ± 51.65^b	395.48 ± 18.82^a	478.44 ± 13.91^a
Day 14	490.43 ± 51.60^a	551.27 ± 29.37^a	493.19 ± 20.33^a	487.66 ± 49.75^a
Day 21	487.66 ± 29.67^a	392.71 ± 20.34^b	379.80 ± 12.86^b	408.38 ± 4.36^b
Superoxide dismutase (U/g Hgb)
Day 0	597.00 ± 127.95^a	578.55 ± 76.78^a	534.31 ± 92.39^a	601.39 ± 25.41^a
Day 7	579.03 ± 35.45^a	444.34 ± 66.22^a	429.10 ± 10.14^a	455.80 ± 38.71^a
Day 14	647.22 ± 50.76^a	773.41 ± 82.01^a	824.29 ± 155.70^a	742.52 ± 62.50^a
Day 21	590.96 ± 21.97^a	633.10 ± 98.83^a	778.74 ± 69.83^a	696.01 ± 33.76^a
Glutathione peroxidase (U/mg Hgb)
Day 0	2.10 ± 0.06^a	1.89 ± 0.10^a	2.03 ± 0.04^a	1.85 ± 0.037^a
Day 7	2.07 ± 0.33^a	1.99 ± 0.35^a	1.71 ± 0.09^a	1.57 ± 0.06^a
Day 14	2.12 ± 0.19^a	2.29 ± 0.10^a	1.71 ± 0.26^a	2.08 ± 0.05^a
Day 21	2.32 ± 0.19^ac	3.43 ± 0.14^b	2.08 ± 0.11^a	2.82 ± 0.08^c
Catalase (μmole H₂O₂ decomposed/min/mg Hgb)
Day 0	1671.04 ± 86.37^a	1509.74 ± 87.40^a	1504.00 ± 174.80^a	1550.88 ± 27.59^a
Day 7	1664.30 ± 96.45^a	1631.50 ± 39.55^a	1549.12 ± 175.18^a	1815.24 ± 80.42^a
Day 14	1576.25 ± 68.60^a	1348.38 ± 143.93^a	2493.87 ± 289.60^b	1494.874 ± 72.93^a
Day 21	1596.01 ± 51.54^ab	1379.00 ± 185.42^b	2039.53 ± 222.02^a	1786.106 ± 129.91^ab
Lipid peroxidation (nmole malondialdehyde formed/mL erythrocytes)
Day 0	5.14 ± 0.68^a	4.06 ± 0.49^a	5.46 ± 1.36^a	4.66 ± 0.21^a
Day 7	5.87 ± 0.42^a	6.50 ± 0.19^ab	7.84 ± 1.10^b	6.15 ± 0.42^ab
Day 14	5.96 ± 0.58^a	8.44 ± 0.98^b	7.99 ± 0.39^bc	6.19 ± 0.31^ac
Day 21	6.38 ± 0.60^a	10.34 ± 1.03^b	9.87 ± 0.96^b	10.22 ± 1.00^b

Within a row, values with different superscripted letters differ significantly (P < 0.05).