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. Author manuscript; available in PMC: 2014 Jul 28.
Published in final edited form as: Circ Res. 2012 May 25;110(11):1525–1537. doi: 10.1161/CIRCRESAHA.111.260026

Figure 6. MicroRNA regulation of cardiac conduction.

Figure 6

Two miRs have been implicated in regulating cardiac conduction: miR-208a and miR-1. miR-208a directly targets the 3′UTR of Gata4 (a direct activator of Cx30.2), but it activates HOP expression by inhibiting a putative HOP inhibitor. miR-1 directly targets the 3′UTR of Irx5, which is responsible for the normal ventricular repolarization sequence by establishing an epicardial-to-endocardial gradient of Kv4.2 expression.