Table 1. The composition, physicochemical properties, and permeability parameters of RHCl-loaded nanoemulsions.
| MS % | CoS % | IPM % | Drug % | Size (nm) | Viscosity (cps×103) | Flux (µg/cm2/h) | LT (h) | |||||||||
| F1 | 20B | 30E | 5 | 0.5 | 14.73 | ± | 1.16 | 8.99 | ± | 0.12 | 44.21 | ± | 5.73 | 4.3 | ± | 1.2 |
| F2 | 25B | 30E | 5 | 0.5 | 12.73 | ± | 1.50 | 9.71 | ± | 0.11 | 48.53 | ± | 5.16 | 3.0 | ± | 0.0 |
| F3 | 30B | 30E | 5 | 0.5 | 21.03 | ± | 7.60 | 9.79 | ± | 0.07 | 25.94 | ± | 3.51 | 4.3 | ± | 0.6 |
| F4 | 30B | 20E | 5 | 0.5 | 14.10 | ± | 0.66 | 19.10 | ± | 0.56 | 20.25 | ± | 4.23 | 5.3 | ± | 0.6 |
| F5 | 20B | 30I | 5 | 0.5 | 14.40 | ± | 2.79 | 6.67. | ± | 0.04 | 65.45 | ± | 13.2 | 3.7 | ± | 0.6 |
| F6 | 30B | 20I | 5 | 0.5 | 12.67 | ± | 0.81 | 13.33. | ± | 0.06 | 30.61 | ± | 2.71 | 3.7 | ± | 0.6 |
| F7 | 15T | 30E | 5 | 0.5 | 107.93 | ± | 7.14 | 11.37 | ± | 0.21 | 13.08 | ± | 0.57 | 4.0 | ± | 0.0 |
RHCl: ropinirole hydrochloride, MS: Mixture surfactant, CoS: Cosurfactant, IPM: Isopropyl myristate,
B: Brij30/Brij35 (4/1); T: Tween80/Span20 (2/3), E: Ethanol, I: Isopropyl alcohol.
LT: lag time