Table 2. The composition, physicochemical properties, and permeability parameters of model RHCl-loaded nanoemulsions provided mixture design.
| X1% | X2% | X3% | Size (nm) | PI | Viscosity (cps×103) | Flux (µg/cm2/h) | LT (h) | |||||||||||
| F01 | 20.0 | 30.0 | 44.5 | 12.1 | ± | 1.1 | 0.36 | ± | 0.07 | 12.73 | ± | 0.21 | 33.04 | ± | 2.72 | 4.0 | ± | 0.6 |
| F02 | 25.9 | 30.0 | 38.6 | 12.5 | ± | 1.6 | 0.45 | ± | 0.06 | 9.79 | ± | 0.07 | 33.98 | ± | 3.71 | 3.7 | ± | 0.6 |
| F03 | 20.0 | 30.0 | 44.5 | 12.6 | ± | 0.2 | 0.41 | ± | 0.06 | 12.67 | ± | 0.06 | 33.76 | ± | 4.54 | 4.0 | ± | 1.0 |
| F04 | 25.9 | 25.9 | 42.7 | 24.5 | ± | 1.5 | 0.32 | ± | 0.04 | 8.82 | ± | 0.07 | 45.67 | ± | 4.93 | 3.7 | ± | 0.6 |
| F05 | 30.0 | 30.0 | 34.5 | 53.2 | ± | 7.3 | 0.57 | ± | 0.12 | 8.52 | ± | 0.02 | 35.53 | ± | 2.31 | 3.7 | ± | 0.6 |
| F06 | 30.0 | 25.7 | 38.8 | 24.4 | ± | 3.6 | 0.30 | ± | 0.03 | 7.80 | ± | 0.05 | 56.93 | ± | 13.16 | 3.0 | ± | 1.0 |
| F07 | 30.0 | 30.0 | 34.5 | 55.5 | ± | 3.8 | 0.61 | ± | 0.03 | 8.60 | ± | 0.11 | 41.23 | ± | 5.91 | 3.7 | ± | 0.6 |
| F08 | 30.0 | 20.0 | 44.5 | 15.4 | ± | 0.8 | 0.32 | ± | 0.06 | 6.55 | ± | 0.00 | 63.23 | ± | 6.32 | 3.0 | ± | 0.0 |
| F09 | 24.5 | 20.0 | 50.0 | 16.1 | ± | 0.8 | 0.26 | ± | 0.05 | 7.75 | ± | 0.03 | 59.91 | ± | 5.30 | 2.7 | ± | 0.6 |
| F10 | 20.0 | 24.5 | 50.0 | 14.3 | ± | 1.2 | 0.34 | ± | 0.06 | 10.99 | ± | 0.06 | 49.80 | ± | 2.13 | 3.0 | ± | 0.0 |
The amounts of RHCl and IPM in formulations were fixed at 0.5% and 5% respectively.
The total amount of three variables of X1 (isopropyl alcohol, 20∼30%), X2(mixture surfactant of Brij30/Brij35 at ratio of 4/1, 20∼30%), and X3 (distilled water, 34.5∼50.0%) was 95%. X1+X2+X3 = 0.95.
LT: lag time; PI: polydispersity index.