Tumor Classification Markers:
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Luminal A–C: FOXA1, TFF3, GATA3, ESR1, KRT8, KRT18, SLC39A6, XBP1, HER2-like: ERBB2, GRB7. |
Basal-like/Triple Negative: EGFR, BIRC5, KRT5, NOTCH1. |
Metastasis to Lung: PTGS2, ID1, MMP2. |
Transcription Factors: AR, ESR1, ESR2, FOXA1, CTNNB1, GATA3, HIC1, JUN, MYC, TP53, TP73, NOTCH1, NR3C1, PGR, PRDM2, RARB, RB1, XBP1. |
Signal Transduction:
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Steroid Receptor-Mediated: AR, BRCA1, PGR, CCNE1, ESR1, ESR2, IGF1, KRT19, CTNNB1, RB1. |
Hedgehog: CCND1, BCL2, GLI1, SNAI2. |
Glucocorticoid: NME1, IGFBP3, NR3C1. |
WNT: CTNNB1, APC, CCND1, SFRP1. |
PI3K/AKT: AKT1, IGF1, ERBB2, IGF1R, PTEN. |
NOTCH: NOTCH1, BIRC5. |
MAPK: TP73, MAPK1, MAPK3, MAPK8. |
Angiogenesis: VEGFA, CTNNB1, CDH13, EGF, ID1, IL6, ERBB2, JUN, SERPINE1, NOTCH1, PLAU, PTEN, SLIT2, THBS1. |
Adhesion: CDH1, CDH13, ADAM23, APC, BCL2, PTEN, CDKN2A, CSF1, CTNNB1, EGFR, TGFB1, THBS1, ERBB2. |
Proteolysis: MMP2, MMP9, ADAM23, CST6, CTSD, PLAU, PYCARD. |
Epithelial to Mesenchymal Transition: NOTCH1, SRC, CTNNB1, TGFB1, TWIST1. |
Cell Cycle: CCNA1, CCND1, APC, BCL2, CCND2, MYC, PTEN, RASSF1, CCNE1, CDK2, CDKN1A, CDKN1C, CDKN2A, JUN, MKI67, RB1, SFN, TP53. |
DNA Damage: TP53, TP73, APC, ATM, CCND1, CDKN1A, MAPK1, BRCA1, BRCA2, MGMT, MLH1, SFN. |
Apoptosis: TP53, TP73, AKT1, BAD, BCL2, CDH1, CDKN1A, CDKN2A, GSTP1, IGF1, IL6, JUN, MUC1, NME1, RARB, APC, SFN, SFRP1, TWIST1. |
Xenobiotic Transport: ABCB1, ABCG2. |