Table 2.
Agent | Inhibition of | Safety data |
---|---|---|
Signal 1 | ||
Eritoran [14] | TLR4 (selective) | Yes |
Glycyrrhizin [16,17] | HMGB1 | Yes |
Ethyl pyruvate [23] | TLR4 | Yes |
Melatonin [25] | TLR4 | Yes |
Curcumin [28] | TLR4 | Yes |
Anti-HMGB1 Ab | HMGB1 | No |
IRS954 | TLR7 and 9 | No |
Signal 2 | ||
GS-9450 [36] | Caspase 1 | Yes |
A438079 | P2X7 | No |
Febuxostat [37] | Xanthine oxidase | Yes |
Allopurinol [38] | Xanthine oxidase | Yes |
Downstream signals | ||
Anakinra [39] | IL-1R | Yes |
Fostamatinib [40] | Syk | Yes |