Table 3.
Performance of eGFR equations (n=26) according to P30
| Equation | Mean GFR (ml/min/1.73 m2) | Mean Error (ml/min/1.73 m2) | Median Percent Error (%) | Mean Absolute Error (ml/min/1.73 m2) | Median Absolute Percent Error (%) | P30 (%) |
|---|---|---|---|---|---|---|
| CKD-EPI | 54.6 (53.6, 55.6) | 0.4 (−0.3, 1.1) | 0.8 (−0.4, 2.0) | 10.6 (10.1, 11.1) | 15.9 (15.0, 16.8) | 78.9 (76.9, 80.8) |
| MDRD Study | 51.1 (50.1, 52.0) | 4.0 (3.3, 4.7) | 6.8 (5.7, 7.9) | 11.0 (10.5, 11.5) | 16.6 (15.7, 17.3) | 78.9 (76.9, 80.8) |
| Virga | 49.5 (48.7, 50.4) | 5.5 (4.8, 6.2) | 8.6 (7.2, 10.0) | 11.7 (11.2, 12.2) | 17.9 (17.1, 18.9) | 76.4 (74.4, 78.4) |
| Walser | 51.2 (50.3, 52.1) | 3.9 (3.1, 4.6) | 5.5 (4.0, 6.4) | 11.8 (11.3, 12.4) | 18.0 (17.1, 18.9) | 74.3 (72.2, 76.3) |
| Nix-J | 49.8 (48.8, 50.8) | 5.3 (4.5, 6.1) | 9.9 (8.6, 11.3) | 12.6 (12.0, 13.2) | 19.4 (18.6, 20.3) | 72.9 (70.7, 75.0) |
| CHUQ | 49.6 (48.8, 50.4) | 5.5 (4.7, 6.3) | 9.4 (8.3, 10.6) | 12.6 (12.0, 13.2) | 19.9 (19.1, 21.1) | 72.5 (70.3, 74.6) |
| Wright | 59.8 (58.8, 60.8) | −4.8 (−5.5, −4.0) | −9.7 (−10.9, −8.5) | 11.6 (11.1, 12.1) | 17.4 (16.4, 18.3) | 72.3 (70.1, 74.4) |
| Gates | 60.8 (59.7, 62.0) | −5.8 (−6.6, −5.0) | −10.5 (−11.9, −9.0) | 12.2 (11.6, 12.8) | 17.7 (16.9, 18.6) | 71.3 (69.1, 73.5) |
| Nankivell-SPK | 46.4 (45.6, 47.2) | 8.6 (7.9, 9.4) | 14.3 (12.9, 15.7) | 13.5 (12.9, 14.1) | 21.4 (20.6, 22.4) | 68.5 (66.2, 70.7) |
| Cockcroft-Gault | 61.8 (60.8, 62.9) | −6.8 (−7.5, −6.1) | −14.1 (−15.7, −12.9) | 12.4 (11.9, 13.0) | 18.9 (17.8, 20.1) | 68.3 (66.0, 70.5) |
| Edwards | 61.6 (60.5, 62.7) | −6.5 (−7.3, −5.7) | −12.1 (−13.6, −10.7) | 13.3 (12.7, 13.9) | 19.4 (18.3, 20.5) | 67.3 (65.0, 69.5) |
| Nix-HPLC | 63.0 (62.0, 64.0) | −8.0 (−8.7, −7.2) | −17.2 (−19.1, −15.5) | 13.3 (12.8, 13.8) | 20.9 (19.8, 22.0) | 65.1 (62.8, 67.3) |
| Yukawa | 62.4 (61.5, 63.2) | −7.3 (−8.1, −6.5) | −15.1 (−16.8, −13.1) | 14.2 (13.6, 14.8) | 21.3 (19.9, 22.6) | 63.7 (61.4, 66.0) |
| BIS1 | 65.2 (63.8, 66.6) | −10.1 (−11.3, −9.0) | −14.9 (−16.8, −13.2) | 16.8 (15.8, 17.7) | 21.7 (20.8, 23.0) | 61.6 (59.3, 63.9) |
| AASK-main | 66.0 (64.7, 67.3) | −10.9 (−11.8, −10.1) | −19.3 (−20.7, −17.8) | 15.7 (15.1, 16.4) | 23.9 (22.8, 25.5) | 59.9 (57.5, 62.2) |
| Mayo | 41.0 (40.2, 41.7) | 14.1 (13.4, 14.8) | 25.0 (24.1, 25.8) | 15.8 (15.1, 16.4) | 26.6 (25.8, 27.4) | 59.0 (56.7, 61.4) |
| Matsuo | 67.4 (66.2, 68.6) | −12.4 (−13.2, −11.6) | −23.5 (−24.9, −22.0) | 15.7 (15.0, 16.3) | 24.7 (23.3, 25.9) | 57.6 (55.3, 60.0) |
| Nankivell* | 66.2 (65.0, 67.4) | −11.2 (−12.1, −10.3) | −23.1 (−24.8, −21.3) | 16.0 (15.3, 16.7) | 25.9 (23.8, 27.2) | 54.8 (52.1, 57.4) |
| Baracskay | 64.9 (64.0, 65.9) | −9.9 (−10.9, −8.8) | −19.6 (−21.8, −16.9) | 18.7 (18.0, 19.5) | 27.8 (26.5, 29.1) | 53.4 (51.0, 55.7) |
| Taylor | 52.1 (50.9, 53.4) | 2.9 (1.8, 4.0) | 3.3 (1.3, 5.5) | 18.0 (17.3, 18.7) | 29.6 (27.9, 30.9) | 50.6 (48.2, 53.0) |
| Robinson | 73.0 (71.4, 74.7) | −18.0 (−19.3, −16.7) | −29.3 (−32.0, −26.3) | 23.7 (22.6, 24.8) | 33.6 (31.5, 35.3) | 46.1 (43.7, 48.5) |
| Mogensen | 71.1 (69.8, 72.4) | −16.0 (−17.0, −15.1) | −30.1 (−32.3, −28.2) | 20.4 (19.7, 21.2) | 33.7 (32.0, 35.5) | 45.5 (43.1, 47.9) |
| AASK-pilot | 76.3 (74.9, 77.6) | −21.2 (−22.2, −20.2) | −38.9 (−41.6, −36.6) | 23.9 (23.0, 24.8) | 40.0 (37.7, 41.9) | 38.9 (36.6, 41.2) |
| Kaji | 31.0 (30.4, 31.6) | 24.1 (23.2, 24.9) | 43.8 (42.7, 45.0) | 24.9 (24.0, 25.8) | 44.4 (43.5, 45.6) | 26.9 (24.9, 29.1) |
| Martin | 98.6 (97.0, 100.2) | −43.5 (−44.7, −42.4) | −80.7 (−83.5, −78.2) | 44.0 (42.8, 45.1) | 80.7 (78.1, 83.5) | 9.6 (8.3, 11.1) |
| Rowe | 122.4 (121.9, 122.9) | −67.3 (−68.4, −66.2) | −129.6 (−134.1, −125.6) | 67.5 (66.5, 68.6) | 129.6 (125.5, 134.1) | 4.9 (4.0, 6.0) |
Note: Data given as value (99.6% confidence interval). All estimates are scaled to 1.73 m2 for validity of comparisons. Equations are ranked by P30 in descending order. The equations that had a P30 ≥60% and mean absolute error ≤20 ml/min/1.73m2 are highlighted in bold and were included in the final analysis where we compared the performance of the CKD-EPI equation or the MDRD Study equations with the alternative equations
P30: Percentage of patients who have absolute percent error ≤30%.; eGFR, estimated glomerular filtration rate; GFR; glomerular filtration rate, MDRD, Modification of Diet in Renal Disease; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; BIS, Berlin Initiative Study; CHUQ, Le Centre hospitalier universitaire de Québec; AASK, African American Study of Kidney Disease and Hypertension; SPK, simultaneous pancreas and kidney; BSA, body surface area; SRM, standard reference material; J, Jaffe
eGFR estimated on 2858 patients on whom serum urea/serum urea nitrogen was available and was in steady state