Table 3. Expression of growth plate cartilage zonal markers in superficial and intermediate/deep zones of articular cartilage.
| Resting Zone Markers | |||||
| Gene Symbol | Superficial ZoneRaw Signal(Upregulated markers: 5) | Intermediate/Deep ZoneRaw Signal(Upregulated markers: 9) | Fold-Change | P-value | |
| Ptn | 2268 | 538 | 4 | Up in SZ | 1.09E-07 |
| Hhip | 363 | 92 | 4 | Up in SZ | 2.19E-07 |
| Col14a1 | 5864 | 1596 | 4 | Up in SZ | 2.80E-11 |
| RGD1562717 | 3695 | 1257 | 3 | Up in SZ | 3.09E-06 |
| Pdgfra | 1280 | 606 | 2 | Up in SZ | 2.78E-06 |
| Efemp1 | 133 | 912 | 7 | Up in IDZ | 7.88E-10 |
| Grem1 | 217 | 1100 | 5 | Up in IDZ | 3.13E-06 |
| Bmp3 | 186 | 919 | 5 | Up in IDZ | 1.27E-06 |
| Lrrn3 | 96 | 404 | 4 | Up in IDZ | 1.22E-05 |
| Shisa3 | 310 | 1196 | 4 | Up in IDZ | 1.15E-08 |
| Sfrp5 | 367 | 1302 | 4 | Up in IDZ | 4.91E-06 |
| Pou3f3 | 438 | 1504 | 3 | Up in IDZ | 2.89E-08 |
| Pcp4 | 1148 | 3930 | 3 | Up in IDZ | 1.98E-07 |
| Ppp1r3b | 250 | 832 | 3 | Up in IDZ | 7.02E-08 |
| Proliferative Zone Markers | |||||
| Gene Symbol | Superficial Zone Raw Signal (Upregulated markers: 3) | Intermediate/Deep Zone Raw Signal (Upregulated markers: 0) | Fold-Change | P -value | |
| Gdf10 | 484 | 184 | 3 | Up in SZ | 8.24E-05 |
| Olfml3 | 2403 | 941 | 3 | Up in SZ | 6.34E-08 |
| Prelp | 3664 | 1463 | 3 | Up in SZ | 3.39E-07 |
| Hypertrophic Zone Markers | |||||
| Gene Symbol | Superficial Zone Raw Signal (Upregulated markers: 27) | Intermediate/Deep Zone Raw Signal (Upregulated markers: 3) | Fold-Change | P -value | |
| RGD1307396 | 542 | 90 | 6 | Up in SZ | 3.93E-06 |
| Fxyd5 | 1358 | 274 | 5 | Up in SZ | 4.10E-06 |
| Col5a2 | 1226 | 249 | 5 | Up in SZ | 1.51E-06 |
| Mmp13 | 3448 | 705 | 5 | Up in SZ | 4.98E-03 |
| Tmsb4x | 376 | 78 | 5 | Up in SZ | 2.14E-06 |
| Ctsk | 1561 | 337 | 5 | Up in SZ | 4.09E-04 |
| Mafb | 1175 | 255 | 5 | Up in SZ | 1.98E-06 |
| Mmp9 | 3761 | 824 | 5 | Up in SZ | 2.48E-03 |
| Spon2 | 1041 | 247 | 4 | Up in SZ | 4.94E-06 |
| Col1a1 | 13700 | 3598 | 4 | Up in SZ | 7.23E-04 |
| Col1a2 | 11867 | 3128 | 4 | Up in SZ | 2.66E-04 |
| B2m | 4002 | 1097 | 4 | Up in SZ | 1.38E-07 |
| Inhba | 410 | 118 | 3 | Up in SZ | 5.10E-06 |
| Adamts1 | 405 | 118 | 3 | Up in SZ | 3.19E-06 |
| Steap4 | 625 | 189 | 3 | Up in SZ | 2.02E-05 |
| Anpep | 703 | 213 | 3 | Up in SZ | 1.85E-05 |
| Tgm2 | 747 | 229 | 3 | Up in SZ | 1.45E-05 |
| Serpine1 | 312 | 99 | 3 | Up in SZ | 3.40E-05 |
| Fgl2 | 212 | 75 | 3 | Up in SZ | 4.35E-06 |
| Emp1 | 3186 | 1148 | 3 | Up in SZ | 3.99E-07 |
| Hspb1 | 475 | 178 | 3 | Up in SZ | 2.62E-06 |
| Pdlim5 | 627 | 246 | 3 | Up in SZ | 2.90E-09 |
| S100a6 | 453 | 195 | 2 | Up in SZ | 1.28E-04 |
| Tnfrsf12a | 472 | 205 | 2 | Up in SZ | 1.98E-06 |
| Ibsp | 262 | 123 | 2 | Up in SZ | 5.42E-02 |
| Ptgis | 492 | 233 | 2 | Up in SZ | 2.65E-05 |
| Rac2 | 334 | 165 | 2 | Up in SZ | 9.58E-03 |
| Alox12 | 64 | 197 | 3 | Up in IDZ | 6.22E-07 |
| Sgms2 | 289 | 881 | 3 | Up in IDZ | 7.12E-06 |
| Gmpr | 184 | 382 | 2 | Up in IDZ | 1.08E-05 |
*SZ, superficial zone; IDZ, intermediate/deep zone.