Table 5. Top signaling pathways implicated by differentially expressed genes between intermediate/deep zone of articular cartilage and resting zone of growth plate cartilage.

Zone	Name	Ratio	P-value	Regulated Genes
Up in IDZ	Role of Osteoblasts,Osteoclasts and Chondrocytesin Rheumatoid Arthritis	6/215 (3%)	3.80E-03	WIF1,FZD4,IGF1,MMP3,DLX5, BMP5
	IGF-1 Signaling	4/97 (4%)	4.68E-03	NOV,IGF1,IGFBP5,IGFBP7
	Growth Hormone Signaling	3/67 (4%)	1.15E-02	GHR,IGF1,A2M
	Hepatic Fibrosis/HepaticStellate Cell Activation	4/133 (3%)	1.41E-02	IGF1,IGFBP5,A2M,COL3A1
	LPS/IL-1 Mediated Inhibitionof RXR Function	5/214 (2%)	1.48E-02	GSTM1,APOE,SLC27A6,HS6ST2, SOD3
	Factors PromotingCardiogenesis in Vertebrates	3/88 (3%)	2.29E-02	TBX5,FZD4,BMP5
	Oncostatin M Signaling	2/33 (6%)	2.29E-02	EPAS1,MMP3
	Inhibition of MatrixMetalloproteases	2/36 (6%)	2.69E-02	MMP3,A2M
	Atherosclerosis Signaling	3/111 (3%)	3.89E-02	APOE,MMP3,COL3A1
	Superoxide RadicalsDegradation	1/6 (17%)	4.17E-02	SOD3
Up in RZ	GADD45 Signaling	4/19 (21%)	2.82E-06	PCNA,CCNE1,CCND1,CCNB1
	Sonic Hedgehog Signaling	4/25 (16%)	1.41E-05	PRKAR2B,PTCH1,HHIP,CCNB1
	Basal Cell CarcinomaSignaling	5/66 (8%)	4.47E-05	BMP3,PTCH1,LEF1,BMP7,HHIP
	Mitotic Roles of Polo-LikeKinase	4/61 (7%)	4.68E-04	CDC20,PTTG1,PLK1,CCNB1
	Axonal Guidance Signaling	9/406 (2%)	5.75E-04	PRKAR2B,LOC680415,MAG,CXCR4, BMP3,PTCH1,BMP7,HHIP,NTN1
	Molecular Mechanisms ofCancer	8/330 (2%)	5.75E-04	CCNE1,PRKAR2B,BMP3, PTCH1,LEF1, BMP7,CCND1,CASP7
	BMP signaling pathway	4/74 (5%)	9.33E-04	PRKAR2B,RUNX2,BMP3,BMP7
	p53 Signaling	4/82 (5%)	1.51E-03	PCNA,BAI1,CCND1,SERPINE2
	Role of Osteoblasts,Osteoclasts and Chondrocytesin Rheumatoid Arthritis	6/215 (3%)	1.66E-03	RUNX2,BMP3,SFRP5,LEF1,BMP7,ALPL
	Factors PromotingCardiogenesis in Vertebrates	4/88 (5%)	1.74E-03	CCNE1,BMP3,LEF1,BMP7

*IDZ, intermediate/deep zone; RZ, resting zone.