Table 5. Top signaling pathways implicated by differentially expressed genes between intermediate/deep zone of articular cartilage and resting zone of growth plate cartilage.
Zone | Name | Ratio | P-value | Regulated Genes |
Up in IDZ | Role of Osteoblasts,Osteoclasts and Chondrocytesin Rheumatoid Arthritis | 6/215 (3%) | 3.80E-03 | WIF1,FZD4,IGF1,MMP3,DLX5, BMP5 |
IGF-1 Signaling | 4/97 (4%) | 4.68E-03 | NOV,IGF1,IGFBP5,IGFBP7 | |
Growth Hormone Signaling | 3/67 (4%) | 1.15E-02 | GHR,IGF1,A2M | |
Hepatic Fibrosis/HepaticStellate Cell Activation | 4/133 (3%) | 1.41E-02 | IGF1,IGFBP5,A2M,COL3A1 | |
LPS/IL-1 Mediated Inhibitionof RXR Function | 5/214 (2%) | 1.48E-02 | GSTM1,APOE,SLC27A6,HS6ST2, SOD3 | |
Factors PromotingCardiogenesis in Vertebrates | 3/88 (3%) | 2.29E-02 | TBX5,FZD4,BMP5 | |
Oncostatin M Signaling | 2/33 (6%) | 2.29E-02 | EPAS1,MMP3 | |
Inhibition of MatrixMetalloproteases | 2/36 (6%) | 2.69E-02 | MMP3,A2M | |
Atherosclerosis Signaling | 3/111 (3%) | 3.89E-02 | APOE,MMP3,COL3A1 | |
Superoxide RadicalsDegradation | 1/6 (17%) | 4.17E-02 | SOD3 | |
Up in RZ | GADD45 Signaling | 4/19 (21%) | 2.82E-06 | PCNA,CCNE1,CCND1,CCNB1 |
Sonic Hedgehog Signaling | 4/25 (16%) | 1.41E-05 | PRKAR2B,PTCH1,HHIP,CCNB1 | |
Basal Cell CarcinomaSignaling | 5/66 (8%) | 4.47E-05 | BMP3,PTCH1,LEF1,BMP7,HHIP | |
Mitotic Roles of Polo-LikeKinase | 4/61 (7%) | 4.68E-04 | CDC20,PTTG1,PLK1,CCNB1 | |
Axonal Guidance Signaling | 9/406 (2%) | 5.75E-04 | PRKAR2B,LOC680415,MAG,CXCR4, BMP3,PTCH1,BMP7,HHIP,NTN1 | |
Molecular Mechanisms ofCancer | 8/330 (2%) | 5.75E-04 | CCNE1,PRKAR2B,BMP3, PTCH1,LEF1, BMP7,CCND1,CASP7 | |
BMP signaling pathway | 4/74 (5%) | 9.33E-04 | PRKAR2B,RUNX2,BMP3,BMP7 | |
p53 Signaling | 4/82 (5%) | 1.51E-03 | PCNA,BAI1,CCND1,SERPINE2 | |
Role of Osteoblasts,Osteoclasts and Chondrocytesin Rheumatoid Arthritis | 6/215 (3%) | 1.66E-03 | RUNX2,BMP3,SFRP5,LEF1,BMP7,ALPL | |
Factors PromotingCardiogenesis in Vertebrates | 4/88 (5%) | 1.74E-03 | CCNE1,BMP3,LEF1,BMP7 |
*IDZ, intermediate/deep zone; RZ, resting zone.