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. 2014 Jul 21;9:3439–3452. doi: 10.2147/IJN.S65353

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© 2014 Song et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Therapeutic effects on mouse ischemic hindlimbs.

Notes: (A) Representative photographs of hindlimbs on days 0, 14, and 28 after treatments. (B) Grading the hindlimb necrosis on day 28 after treatment. Three grades were used to measure the degree of limb necrosis: I, necrosis in the nail; II, necrosis in the toe; and III, necrosis in the distal half of the foot. (C) The blood reperfusion ratio in ischemic hindlimbs. *P<0.05 versus all other groups; ^#P<0.05 versus the saline group. (D) Representative immunohistochemistry photographs of sections in ischemic hindlimbs. Capillaries were marked in brown. Scale bar =25 μm. (E) Quantification of capillary density. *P<0.05 versus the saline, L64, and pSC-HIF1α groups; ^#P<0.05 versus the saline group (n=7). Pluronic^® L64 (Sigma-Aldrich, St Louis, MO, USA).

Abbreviations: CMV, cytomegalovirus; L64, Pluronic^® L64; SC, CMV promoter/SV40 enhancer; HIF-1α^tri, hypoxia-inducible factor 1-alpha triple mutant; SV40E, SV40 enhancer.