Figure 8. Cartoon of proposed EzrA domain function.

Deletion analysis suggests EzrA has four major functional domains. The primary function of EzrA's TM domain is to concentrate EzrA at the plasma membrane where it can function most effectively to modulate FtsZ assembly at cell poles and in the cytokinetic ring. CC1 and CC2 are required for EzrA mediated inhibition of aberrant FtsZ rings at cell poles but are largely dispensable for inhibition of FtsZ assembly at midcell. CC3 or CC4 function in concert with the QNR to mediate interactions between EzrA and FtsZ throughout the cell.