Table 2.
The adjusted odd ratios between asthma status and the CHI3L1 polymorphisms rs1538372 and rs10399931 according to three inheritance modes
| Categories | Case/Control | OR (95% CI) | aOR (95% CI) a |
|---|---|---|---|
| rs1538372 |
|
|
|
| Co-dominant genotype |
|
|
|
| TT |
65/90 |
1 |
1 |
| TC |
293/312 |
1.3 (0.91–1.86) |
1.54 (0.98–2.43) |
| CC |
270/226 |
1.65 (1.15–2.38) |
1.97 (1.23–3.14) |
| Recessive genotype |
|
|
|
| TT + TC |
358/402 |
1 |
1 |
| CC |
270/226 |
1.34 (1.07–1.68) |
1.39 (1.04–1.86) |
| Dominant genotype |
|
|
|
| TT |
65/90 |
1 |
1 |
| TC + CC |
563/538 |
1.45 (1.03–2.04) |
1.72 (1.11–2.66) |
| rs10399931 |
|
|
|
| Co-dominant genotype |
|
|
|
| AA |
72/90 |
1 |
1 |
| GA |
286/307 |
1.16 (0.82–1.65) |
1.36 (0.88–2.10) |
| GG |
270/229 |
1.47 (1.03–2.11) |
1.77 (1.13–2.77) |
| Recessive genotype |
|
|
|
| AA + GA |
358/397 |
1 |
1 |
| GG |
270/229 |
1.31 (1.04–1.64) |
1.39 (1.04–1.86) |
| Dominant genotype |
|
|
|
| AA |
72/90 |
1 |
1 |
| GA + GG | 556/536 | 1.30 (0.93–1.81) | 1.53 (1.01–2.32) |
aAdjusted odds ratio and 95% confidence intervals (aOR and 95% CI) are shown using multiple logistic regressions to control variables, including sex, age, BMI, logIgE, smoking, pet exposure, indoor incense burning, and parents’ asthma history.