Figure 2.

A. MDA-MB-231 and MDA-MB-468 breast cancer cells were transfected with non-specific pre-miRNA controls (NS) or pre-miR-10b, as described under Methods section. Relative expression of miR-10b was determined by quantitative RT-PCR. RNU48 was used as miRNA control against which the data was normalized. B. miR-10b-trasfected MDA-MB-231 (MDA-MB-231-miR-10b) and MDA-MB-468 (MDA-MB-468-miR-10b) cells exhibited significantly increased invasiveness, compared to control (non-specific pre-miR-transfected cells). *p <0.05