Table 2.
Univariate and multivariate Cox regression analysis of overall survival in patients with colon cancer
| Features | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| age (years), ≥ 70 vs. < 70 | 1.755 (0.941-3.273) | 0.077 | ||
| sex, male v female | 1.203 (0.672-2.156) | 0.534 | ||
| tumor size (cm), ≥ 6 vs. < 6 | 0.761 (0.423-1.370) | 0.363 | ||
| tumor differentiation, poor vs well, moderate | 0.640 (0.358-1.144) | 0.132 | ||
| TNM stage, III+IV vs. I+II | 2.925 (1.628-5.258) | < 0.001 | 4.684 (1.292-16.981) | 0.019 |
| LNM, yes vs. no | 2.990 (1.664-5.374) | < 0.001 | 2.170 (0.473-9.960) | 0.319 |
| miR-9-1, high vs. low | 1.481 (0.826-2.653) | 0.187 | ||
| miR-203-3p high vs. low | 1.384 (0.774-2.475) | 0.273 | ||
| miR-221-3p, high vs. low | 2.416 (1.314-4.445) | 0.005 | 2.043 (1.095-3.812) | 0.025 |
| miR-342-3p, high vs. low | 1.807 (1.003-3.253) | 0.049 | 1.625 (0.895-2.950) | 0.110 |
| miR-491-5p, high vs. low | 1.868 (1.032-3.384) | 0.039 | 1.605 (0.878-2.934) | 0.125 |