Table II.
Association of ARTN and GFRα1 expression with clinicopathological parameters from patients with LSCC.
| ARTN | GFRα1 | ||||
|---|---|---|---|---|---|
|
|
|
||||
| Parameter | n | Expression, n (%) | P-value | Expression, n (%) | P-value |
| Age (years) | |||||
| ≤60 | 40 | 19 (47.5) | 0.235 | 17 (42.5) | 0.105 |
| >60 | 36 | 22 (61.1) | 22 (61.1) | ||
| Gender | |||||
| Male | 70 | 39 (55.7) | 0.291 | 37 (52.9) | 0.358 |
| Female | 6 | 2 (33.3) | 2 (33.3) | ||
| Tumor site | |||||
| Supraglottic | 22 | 14 (63.6) | 0.521 | 15 (68.2) | 0.131 |
| Glottic | 45 | 23 (51.1) | 19 (42.2) | ||
| Subglottic | 9 | 4 (44.4) | 5 (51.3) | ||
| Tumor differentiation | |||||
| Well | 28 | 17 (60.7) | 0.122 | 16 (57.1) | 0.681 |
| Moderate | 32 | 19 (59.4) | 16 (50.0) | ||
| Poor | 16 | 5 (31.3) | 7 (43.8) | ||
| pTNM stage | |||||
| I–II | 35 | 14 (40.0) | 0.024a | 12 (34.3) | 0.006a |
| III–IV | 41 | 27 (65.9) | 27 (65.9) | ||
| Lymph node metastasis | |||||
| Yes | 26 | 13 (50.0) | 0.619 | 11 (42.3) | 0.257 |
| No | 50 | 28 (56.0) | 28 (56.0) | ||
a
P<0.05.
LSCC, laryngeal squamous cell carcinoma; ARTN, artemin; GFRα1, GDNF receptor α1.