Table 1.
Factors | Historical Controls | Current Cohort | P-value |
---|---|---|---|
Number of patients | 30 | 34 | NA |
Median age (year) | 55 (19–69) | 56 (36–67) | .24 |
Median weight (kg) | 85 (50–134) | 80 (52–111) | .08 |
CMV-positive recipients | 12 (40%) | 24 (71%) | .02 |
Median infused nucleated cell dose × 108/kg | 0.35 (0.21–0.68) | 0.35 (0.22–0.59) | .94 |
Median infused CD34+ cell dose × 106/kg | 0.44 (0.07–1.66) | 0.38 (0.14–1.32) | .27 |
Median time to follow up (day) | 219 (7–1056) | 339 (31–765) | .59 |
HLA match (worst match) | <.01 | ||
6 of 6 | 0 | 1 (3%) | |
5 of 6 | 0 | 16 (47%) | |
4 of 6 | 30 (100%) | 17 (50%) | |
No. of UCB recipients (%) | 1.00 | ||
Single unit | 1 (3%) | 2 (6%) | |
Double unit | 29 (97%) | 32 (94%) | |
No. with malignant diagnosis at Tx (%) | 28 (93%) | 33 (97%) | .60 |
EBV subgroups | 6 | 8 | .10 |
Viremia | 1 (3%) | 6 (18%) | |
PTLD | 5 (17%) | 2 (6%) |
P values for the comparison of categorical and continuous variables were performed from the Fisher’s exact test and wilcoxon singed rank test, respectively.