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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Parasite Immunol. 2014 Aug;36(8):367–376. doi: 10.1111/pim.12100

Figure 1. Parasite species and host responses influence disease outcome.

Figure 1

Leishmania infects macrophages early during infection: 1) infection via the introduction of infective metacyclic promastigotes via an insect bite, 2) initial infection of host macrophages, 3) conversion to intracellular replicating form of the parasite (amastigote), and 4) progression to a complex host-parasite interaction culminating in diseases with distinct clinical forms.