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. 2014 Jul 20;20:1255–1262. doi: 10.12659/MSM.890598

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© Med Sci Monit, 2014

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License

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(A) Claudin 1 positivity in non-neoplastic surface epithelium, in situ carcinoma, and adenocarcinoma (Claudin 1 ×100). (B) Claudin 1 score 0: Same expression in non-neoplastic mucosa and adenocarcinoma (Claudin 1 ×40). (C) Claudin 1 score 3: Positive staining in non-neoplastic mucosa and complete loss of expression in adenocarcinoma (Claudin 1 ×40). (D) Claudin 1 score 0: Complete membranous Claudin 4 positivity in adenocarcinoma (Claudin 4 ×200). (E) Claudin 4 score 0: Same membranous expression in adenocarcinoma and non-neoplastic mucosa (Claudin 4 ×40). (F) Claudin 4 score 3: Complete loss of expression in adenocarcinoma (Claudin 4 ×200). (G) Claudin 7 score 0: Same membranous expression in adenocarcinoma and non-neoplastic mucosa (Claudin 7 ×40). (H) Claudin 7 score 2: Loss of expression of more than 2/3 in adenocarcinoma (Claudin 7 ×40). (I) Claudin 7 score 3: Membranous staining in non-neoplastic mucosal glands and complete expression loss in poorly differentiated adenocarcinoma (Claudin 7 ×100).