Table 1.
Relation between demographic and tumor characteristics of patients based on Claudin 1 expression.
| Claudin 1 mild loss N (%) | Claudin 1 modarate to marked loss N (%) | P value | |
|---|---|---|---|
| Sex | 0.334 | ||
| Female | 9 (52.9) | 21 (39.6) | |
| Male | 8 (47.1) | 32 (60.4) | |
|
| |||
| Age | 62.5±13.5 | 61.9±14 | 0.8 |
|
| |||
| T stage | 0.004 | ||
| T2 | 1 (5.9) | 1 (1.9) | |
| T3 | 16 (94.1) | 33 (62.3) | |
| T4 | 0 | 19 (27.1) | |
|
| |||
| N status | |||
| Node negative | 15 (88.2) | 13 (25.4) | <0.001 |
| Node positive | 2 (11.8) | 40 (75.5) | |
|
| |||
| M status | 0.214 | ||
| Metastasis negative | 15 (88.2) | 39 (73.6) | |
| Metastasis positive | 2 (11.8) | 14 (26.4) | |
|
| |||
| Stage | |||
| Stage 1 | 1 (5.9) | 0 | |
| Stage 2 | 14 (82.4) | 11 (20.8) | <0.001 |
| Stage 3 | 0 | 29 (54.7) | |
| Stage 4 | 2 (11.8) | 13 (24.5) | |
|
| |||
| Histological sub-type | 0.552 | ||
| Conventional adenocarcinoma | 15 (88.2) | 42 (79.2) | |
| Mucinous adenocarcinoma | 2 (11.8) | 8 (15.1) | |
| Signet ring cell adenocarcinoma | 0 | 3 (5.7) | |
|
| |||
| Grade | 0.026 | ||
| Grade 1 | 15 (88.2) | 31 (58.5) | |
| Grade 2 | 2 (11.8) | 22 (41.5) | |
|
| |||
| Perineural invasion | 0.04 | ||
| Negative | 7 (41.1) | 9 (17) | |
| Positive | 10 (58.8) | 44 (83) | |
|
| |||
| Lymphovascular invasion | 0.024 | ||
| Negative | 7 (41.1) | 8 (15.1) | |
| Positive | 10 (58.8) | 45 (84.9) | |
|
| |||
| Lymphocytic response | 0.009 | ||
| Negative | 7 (41.1) | 40 (%75.5) | |
| Positive | 10 (58.8) | 13 (24.5) | |