Figure 2.

Infusion with high levels of glucose increases the expression levels of cholesterol biosynthesis genes in rat islets in vivo. Sprague Dawley rats were infused with 50% glucose or saline for 24 h (n=5). The islets were isolated and the expression levels of mRNA were detected by quantitative polymerase chain reaction (qPCR). Data are expressed as mean ± standard error of the mean. ^*P<0.05 vs. saline treatment. Hmgcs1, 3-hydroxy-3-methylglutaryl-CoA synthase 1; Hmgcr, 3-hydroxy-3-methylglutaryl-CoA reductase; Idi1, isopentenyl-diphosphate δ-isomerase 1; Sqle, squalene epoxidase; Mvd, mevalonate (diphospho) decarboxylase; Dhcr7, 7-dehydrocholesterol reductase.