Table 1.

Differentially expressed miRNAs in gastrointestinal (GI) tract cancers.

miRNAs	Type of Cancer	Status	Identified miRNA Targets	Ref.
miR-205	Esophageal cancer	Up	ZEB1 and ZEB2	[34]
miR-31	Esophageal cancer	Up	KSR2, EMP1 RGS4	[35]
miR-21	Esophageal cancer	Up	cdc25A, PTEN	[33–34, 37]
miR-143, miR-145, miR-133a, miR-133b	Esophageal cancer	Down	FSCN1	[33–34, 40]
miR-375	Esophageal cancer	Down	JAK2 and c-MYC	[34]
miR-143	Esophageal cancer	Down	DNMT3A	[40]
miR-21 and miR-20a	Gastric cancer	Up	PTEN	[36, 40, 46]
miR-129-1-3p, miR-129-2-3p	Gastric cancer	Down	CP110, TOCA1, ABLIM1,SOX2	[46]
miR-199a-3p	Gastric cancer	Up	CD44	[47]
miR-223	Gastric cancer	Up	SH2B3, CDR2, CARM1	[40]
miR-146a	Gastric cancer	Up	SOCS1	[50]
miR1-148a	Gastric cancer	Up	DNMT3B	[50]
miR-206	Gastric cancer	Down	BCL2, BDNF	[44–45, 52]
miR-200c	Gastric cancer	Up	TrkB	[44–45, 52]
miR-21	Colon cancer	Up	cdc25A, PTEN, E2F, MYC, NFKB, β-Catenin	[108–112,125]
miR-596	Colon cancer	Up	LGALS3BP	[128]
miR-31	Colon cancer	Up	KSR2, EMP1 RGS4	[113–115]
miR-200c	Colon cancer	Up	ZEB, CDH1, PLS1, LSR, EPS8L2	[116]
miR-203	Colon cancer	Up	p63, SOCS3), c-jun (AP-1)	[106,118]
miR-96	Colon cancer	Up	FOXA3a, FOXO1, RAD51, REV1	[121]
miR-720	Colon cancer	Up	TWIST	[121–122]
miR-135b	Colon cancer	Up	LATS2, β-TrCP, NDR2 and LZTS1	[121,123]
miR-106b-5p	Colon cancer	Up	RBL1 RBL2 and CASP8	[124]
miR-133b	Colon cancer	Down	(MCL-1), BCL2L2, c-Met FSCN1	[121]
miR-143	Colon cancer	Down	DNMT3A	[121]
miR-215	Colon cancer	Down	MDM2, TYMS and SIP1/ZEB2	[123]
miR-378	Colon cancer	Down	IGF1R	[123]
miR-442a	Colon cancer	Down	CYP7A1	[123]
miR-29c	Colon cancer	Down	SIRT1	[126]
miR-103	Colon cancer	Down	DAPK and KLF4	[128]
miR-145	Colon cancer	Down	MYC, CCND2, ADAM17	[125]
miR-375	Colon cancer	Down	p53	[123]