Fig. 3.
Enhanced cell kill by carboplatin nanoparticles. MA148, A549, MDA-MB-231, and NCI-ADR/RES were treated with different concentrations of carboplatin in solution or encapsulated in nanoparticles for 3 days. MTS assay was performed each day to determine the percent cell survival using untreated cells as control. Comparison of cell survival as a function of carboplatin concentration and the IC50 of the treatments in a MA148 after 1 day, b MA148 after 2 days, c A549 after 2 days, d MDA-MB-231 after 3 days, and e NCI-ADR/RES after 3 days are plotted. f Cells survival after 3 days of treatment with different concentration of control nanoparticles demonstrates lack of toxicity due to nanoparticles themselves. Data shown is mean ± SD, n = 3. *P < 0.01