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Kinetics and Model Fitting for Carboplatin Release from Nanoparticles
| Model | Constraints | Fitting parameters | Slope | R2 |
|---|---|---|---|---|
| Higuchi | – | F vs. T1/2 | 0.431 | 0.986 |
| Zero order | Up to 3 days | Qt vs. T | 20.4 | 0.993 |
| Zero order | – | Qt vs. T | 17.1 | 0.939 |
| First order | Up to 5 days | Log (Qt) vs. T | −0.178 | 0.968 |
| Korsmeyer-Peppas | Less than 60% release | log (F) vs. log (T) | 0.632 | 0.966 |
Where: F Fraction of Drug Released, T Time, and Q t Percent Drug Released at Time t
