Table II.
Lung Pharmacokinetic Parameters of TFF TACMAN (1:1) and Micronized TACMAN (1:1) Following Single-Dose Exposure to Dry Powder Aerosols Generated from a Rotating Brush Generator. All the Parameters Were Calculated Based on Average Lung Concentration (n = 5)
| Pharmacokinetic parameters | TFF TACMAN (1:1) | Micronized TACMAN (1:1) |
|---|---|---|
| AUC0–24h(ng h/g) | 1,707.47 | 729.53 |
| K10 (h−1) | 0.56 | 2.64 |
| K12 (h−1) | 2.16 | 1.70 |
| K21 (h−1) | 0.20 | 0.45 |
| C max (ng/g) | 948.20 | 1,924.83 |
| CL (ng/(h ng/g)) | 2.93 | 6.85 |
| MRT (h) | 21.18 | 1.82 |
| Model fit (R 2) | 0.9985 | 0.9999 |
AUC area under the concentration–time curve, CL clearance rate, MRT mean residence time