1. Introduction		798
2. Mechanism of Action		799
3. Elucidation of Prodrug Activation		800
	3.1. The Chemistry of MTZ and ETZ	801
4. Kinetic Considerations		805
	4.1 Prodrug Activation Kinetics	805
	4.2. Ultimate Electrophile Lifetime	807
5. Temozolomide Co-crystals		807
6. Synthesis of Temozolomide and the Imidazotetrazine Core		810
7. Synthesis of Structural Analogues		817
	7.1. Alternative Cores	817
	7.2. 6- and 8-Analogues	819
	7.3. 3-Analogues	822
8. Design of MGMT/MMR-Independent Anti-Cancer Agents		825
	8.1. Introduction to NGP Analogues	826
	8.2. Synthesis of Novel N-Linked Imidazotetrazine Dimers	828
	8.3. Properties and Activity of N-Linked Compounds	829
9. Conclusions		931