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. 2014 Jul 10;6(7):2024–2040. doi: 10.3390/toxins6072024

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

The 2932 amino acid sequence of Mcf toxin with three potential functional domains highlighted in boxes. First box (from 905 to 919) at the N-terminus, carrying a BH3-like consensus domain, suggests the protein may be pro-apoptotic. Second box represents a domain (from 1608 to 2280) has the similarity to the Clostridium difficile toxin B (CdtB), responsible for gut destruction. Third box, at the C-terminal (from 2556 to 2932), carries a homolog sequence of ApxIVA from Actinobacillus pleuropneumoniae, an RTX-like toxin.