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. 2014 Jul 23;6(7):2177–2193. doi: 10.3390/toxins6072177

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Inhibitory effects of wild-type and mutant JZTX-V on rNa_V1.4 current. (a) Dose-response inhibitory curves for wild-type and mutant JZTX-V (W5A, M6A, and W7A) on wild-type rNa_V1.4. Compared with wild-type JZTX-V, W5A, M6A, and W7A mutants significantly reduce binding affinity to the rNa_V1.4 channel; (b) Dose-response inhibitory curves for wild-type and mutant JZTX-V (K22A and R20A) on wild-type rNa_V1.4. Compared with wild-type JZTX-V, K22A and R20A mutants significantly reduce affinity to rNa_V1.4; (c) The column graph (left) and the box plot (right) show the IC₅₀ values of JZTX-V and its mutants, as described.