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. 2014 Jul 14;12(7):4148–4164. doi: 10.3390/md12074148

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Myeloid differentiation primary response 88 (MyD88) signaling pathway is essential for ascophyllan-induced DC maturation. C57BL/6 or MyD88^−/− mice received i.v. injection of phosphate buffered saline (PBS) or 50 mg/kg ascophyllan and were analyzed 24 h later. (A) Percentage of lineage⁻CD11c⁺ cDCs and CD8α⁺ and CD8α⁻ cDCs was analyzed by flow cytometry (left panels). Absolute numbers of spleen cDCs and cDC subsets were shown (right panels); (B) Expression levels of CD40, CD80, CD86, MHC class I and MHC class II were measured by flow cytometry; (C) IL-6, IL-12p70 and TNF-α concentrations in sera were shown. All data are representative or the average of analyses of six samples for each group.