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. 1978 Feb;75(2):1021–1023. doi: 10.1073/pnas.75.2.1021

Nerve growth factor increases activity of ornithine decarboxylase in rat brain

Michael E Lewis 1, J Lakshmanan 1, K Nagaiah 1, Paul C MacDonnell 1, Gordon Guroff 1
PMCID: PMC411392  PMID: 16592486

Abstract

Intraventricular administration of nanogram quantities of nerve growth factor to adult rats results in a marked increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in the brain. The increase occurs in all major brain regions and the activity is maximal by 7.5 hr after administration. The enzyme response to nerve growth factor increases in magnitude during maturation; the relative increase in ornithine decarboxylase activity in adult animals is much greater than that in young. Neither insulin nor bovine growth hormone was able to increase ornithine decarboxylase activity to the same extent as did nerve growth factor. When brain was separated into neuronal- and glial-enriched fractions, induction of ornithine decarboxylase was found in both, but a greater increase was observed in the glial fraction.

Keywords: central nervous system, induction in glial cells, maturation

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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