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. 2014 Jul 28;211(8):1657–1672. doi: 10.1084/jem.20131800

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© 2014 Chu et al.

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Figure 2. — Eosinophils are required for induction of Th2 immunity to oral antigen. WT, ΔdblGATA1 (GATA), ΔdblGATA1 mice that received eosinophils weekly (GATA+Eos), or mixed BM chimeras were kept naive or administered PN+CT i.g. weekly for 4 wk. BM chimeras were generated by mixing 80% WT or ΔdblGATA1 BM with 20% il4^−/− BM, resulting in mice with il4^+/+ or il4^−/− eosinophil compartments, respectively. (A and B, top left) Serum PN-specific (PN-) IgG1 and PN-IgE at week 5. (A and B, top right) Clinical anaphylaxis assessment of hypothermia and vascular leakage after i.p. challenge at week 5. (A and B, bottom) Th2 cytokine production from PN-stimulated splenocytes. (C) SI LP eosinophils in WT, eosinophil-deficient, and eosinophil-reconstituted mice. Mean ± SEM, n = 3–12 from 3–5 experiments. *, P < 0.05 versus WT.