Table 3. Association of PSA genotype with categorical phenotypes.
| rs266882 | rs925013 | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Genotype | Node(−) | Node(+) | Genotype | Node(−) | Node(+) | |||
|
| ||||||||
| Lymph node invasion | GG | 234 (25.55) | 22 (38.60) | AA | 558 (60.85) | 34 (61.82) | ||
| AG | 458 (50.00) | 18 (31.58) | AG | 303 (33.04) | 18 (32.73) | |||
| AA | 224 (24.45) | 17 (29.82) | GG | 56 (6.11) | 3 (5.45) | |||
| P* | 0.02 | P† | 0.98 | |||||
| Genotype | Cure | Recur | Genotype | Cure | Recur | |||
|
| ||||||||
| Disease status | GG | 212 (25.73) | 44 (28.95) | AA | 503 (61.04) | 92 (60.93) | ||
| AG | 407 (49.39) | 72 (47.37) | AG | 271 (32.89) | 51 (33.77) | |||
| AA | 205 (24.88) | 36 (23.68) | GG | 50 (6.07) | 8 (5.30) | |||
| P* | 0.71 | P* | 0.92 | |||||
| Genotype | 0 | >0 | Genotype | 0 | >0 | |||
|
| ||||||||
| Intraductal‡ | GG | 206 (25.72) | 52 (30.06) | AA | 491 (61.30) | 104 (60.47) | ||
| AG | 391 (48.81) | 84 (48.55) | AG | 259 (32.33) | 60 (34.88) | |||
| AA | 204 (25.47) | 37 (21.39) | GG | 51 (6.37) | 8 (4.65) | |||
| P* | 0.37 | P* | 0.61 | |||||
| Genotype | Peripheral zone | Transition zone | Genotype | Peripheral zone | Transition zone | |||
|
| ||||||||
| Location | GG | 204 (25.76) | 41 (29.83) | AA | 488 (61.85) | 83 (59.71) | ||
| AG | 389 (49.12) | 62 (45.26) | AG | 254 (32.19) | 48 (34.53) | |||
| AA | 199 (25.13) | 34 (24.82) | GG | 47 (5.96) | 8 (5.76) | |||
| P* | 0.57 | P* | 0.86 | |||||
| Genotype | * | + | − | Genotype | * | + | − | |
|
| ||||||||
| Seminal vesicle invasion | GG | 13 (25.49) | 18 (33.96) | 227 (26.00) | AA | 38 (71.70) | 26 (50.00) | 531 (60.96) |
| AG | 24 (47.06) | 24 (45.28) | 430 (49.26) | AG | 12 (22.64) | 23 (44.23) | 287 (32.95) | |
| AA | 14 (27.45) | 11 (20.75) | 216 (24.74) | GG | 3 (5.66) | 3 (5.77) | 53 (6.08) | |
| P* | 0.75 | P* | 0.22 | |||||
NOTE: Genotype numbers: n (%).
*
P values based on χ2 test.
†
P values based on Fisher's exact test.
‡
Intraductal categorized by absence (0) or presence (>0). Treating as a continuous variable based on percent of tumor was not significant (data not shown).