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. 2014 Jul 29;34(4):e00125. doi: 10.1042/BSR20140008

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© 2014 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) A dorsal view of Drosophila third instar larval brain which contains three main neurogenic regions: central brain (CB), optic lobe (OL) and ventral nerve cord (VNC). Type I neuroblasts (in red) and type II neuroblasts (in purple) are located at CB. (B) Type I neuroblasts divide asymmetrically to self-renew and produce a GMC (in light red). GMC divides one more time to generate neurons (in grey). (C) Type II neuroblasts divide unequally to generate a self-renewing neuroblast and an immature intermediate neural progenitor (INP, in yellow). After maturation, the INP (in orange) divides asymmetrically to self-renew and generate a GMC.