Table 1.
Nomenclature and characteristics of chemokines and chemokine receptors.1
| Systematic Name | Common synonym 2 | Class/Expression | Receptor | Cells Attracted |
|---|---|---|---|---|
| CXCL1 | GROα | ELR+, Inducible | CXCR2, CXCR1 | neutrophils |
| CXCL2 | GROβ | ELR+, Inducible | CXCR2 | neutrophils |
| CXCL3 | GROγ | ELR+, Inducible | CXCR2 | neutrophils |
| CXCL4 | PF4 | ELR-, Inducible | ?3 | fibroblasts, endothelial cells |
| CXCL5 | ENA-78 | ELR+, Inducible | CXCR2 | neutrophils |
| CXCL6 | GCP-2 | ELR+, Inducible | CXCR2 | neutrophils, macrophages |
| CXCL7 | NAP-2 | ELR+, Inducible | CXCR2 | neutrophils |
| CXCL8 | IL-8 | ELR+, Inducible | CXCR1, CXCR2 | neutrophils, macrophages |
| CXCL9 | Mig | ELR-, Inducible | CXCR3 | Th1 T cells, NK cells |
| CXCL10 | IP-10 | ELR-, Inducible | CXCR3 | Th1 T cells, NK cells |
| CXCL11 | I-TAC | ELR-, Inducible | CXCR3 | Th1 T cells, NK cells |
| CXCL12 | SDF-1 | ELR-, Constitutive | CXCR4, CXCR7 | CD34+ progenitor cells and most hematopoietic cell types |
| CXCL13 | BCA-1 | ELR-, Constitutive | CXCR5 | naive B cells, CD4+ T cells |
| CXCL14 | BRAK | ELR-, Constitutive | ? | monocytes, immature dendritic cells, NK cells |
| CXCL16 | SR-PSOX | ELR-, Constitutive | CXCR6 | naïve CD8+ T cells, subsets of activated memory CD4+ T cells, NK-T cells |
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| CCL1 | I-309 | Inducible | CCR8 | monocytes, T cells, B cells |
| CCL2 | MCP-1 | Inducible | CCR2 | monocytes, T cells, NK cells, immature dendritic cells |
| CCL3 | MIP-1α | Inducible | CCR1, CCR5 | monocytes, macrophages, NK cells, T cells, Th1 T cells, Th2 T cells, immature dendritic cells |
| CCL4 | MIP-1β | Inducible | CCR5, CCR8 | monocytes, macrophages, T cells, Th1 T cells, immature dendritic cells |
| CCL5 | RANTES | Inducible | CCR1, CCR3, CCR5 | monocytes, macrophages, eosinophils, NK cells, T cells, Th1 T cells, immature dendritic cells |
| CCL7 | MCP-3 | Inducible | CCR1, CCR2, CCR3 | monocytes, macrophages, NK cells, T cells, immature dendritic cells |
| CCL8 | MCP-2 | Inducible | CCR3 | eosinophils, basophils, mast cells, Th2 T cells |
| CCL11 | Eotaxin | Inducible | CCR3 | eosinophils, basophils, mast cells, Th2 T cells |
| CCL13 | MCP-4 | Inducible | CCR2, CCR3 | monocytes, T cells, NK cells, immature dendritic cells, eosinophils, basophils, mast cells, Th2 T cells |
| CCL14 | HCC-1 | ? | CCR1 | monocytes, macrophages, NK cells, T cells |
| CCL15 | HCC-2 | ? | CCR1, CCR3 | monocytes, macrophages, NK cells, T cells, eosinophils, basophils, mast cells, Th2 T cells |
| CCL16 | HCC-4 | ? | CCR1 | monocytes, macrophages NK cells, T cells |
| CCL17 | TARC | Inducible/constitutive | CCR4 | Th2 T cells, macrophages |
| CCL18 | PARC | Constitutive | ? | T cells |
| CCL19 | MIP-3β/ELC | Constitutive | CCR7 | T cells, B cells, mature dendritic cells |
| CCL20 | MIP-3α/LARC | Inducible/Constitutive | CCR6 | T cells, B cells, immature dendritic cells |
| CCL21 | SLC | Constitutive | CCR7 | T cells, B cells, mature dendritic cells |
| CCL22 | MDC | Inducible/Constitutive | CCR4 | Th2 T cells, macrophages |
| CCL23 | MPIF1 | CCR1 | ||
| CCL24 | Eotaxin-2 | Inducible | CCR3 | eosinophils, basophils, mast cells, Th2 T cells |
| CCL25 | TECK | Constitutive | CCR9 | thymocytes, T cells |
| CCL26 | Eotaxin-3 | Inducible | CCR3 | eosinophils, basophils, mast cells, Th2 T cells |
| CCL27 | CTACK | Constitutive | CCR10 | T cells, monocytes, B cells, immature dendritic cells |
| CCL28 | MEC | Constitutive | CCR10, CCR3 | T cells |
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| XCL1 | lymphotactin | ? | XCR1 | T cells, natural killer cells |
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| CX3CL1 | fractalkine | Inducible/Constitutive | CX3CR1 | T cells, monocytes, neutrophils |
CXCL15, CCL6, CCL9/CCL10, and CCL12 represent the mouse chemokines lungkine, C10, MRP-2, and MCP-5 for which the human orthologs have yet to be identified.
abbreviations used: BCA, B cell-activating chemokine; BRAK, breast and kidney chemokine; CTACK, cutaneous T cell-attracting chemokine; ENA, epithelial neutrophil attractant; ELC, Epstein-Barr virus-induced receptor ligand chemokine; GCP, granulocyte chemoattractant protein; GRO, growth-related oncogene; HCC, hemofiltrate CC-chemokine; IP, γ-interferon-induced protein; I-TAC, interferon-inducible T cell α chemoattractant; LARC, liver and activation-related chemokine; MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; MEC, mucosa-associated epithelial chemokine; MIG, monokine induced by γ-interferon; MIP, macrophage inflammatory protein; NAP, neutrophil activating protein; PARC, pulmonary and activation-regulated chemokine; PF, platelet-factor; RANTES, regulated on activation normal T cell expressed and secreted; SDF, stromal cell-derived factor; SLC, secondary lymphoid tissue chemokine; SR-PSOX, scavenger receptor for phosphatidylserine and oxidized lipoprotein; TARC, thymus and activation related chemokine; TECK, thymus expressed chemokine.
Question mark indicates unknown receptor or regulation pattern.