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. Author manuscript; available in PMC: 2014 Jul 29.
Published in final edited form as: Future Neurol. 2011 Jan;6(1):113–125. doi: 10.2217/fnl.10.80

Figure 2. Model of Reelin, apoE, neurofibromatosis 1, CBP, secretin and Ube3a at the synapse.

Figure 2

The molecular machinery associated with signaling of Reelin, apoE, NF1, CBP, secretin and Ube3a are shown in the postsynaptic cell. Dotted lines are used to indicated transition through other signaling machinery not included (e.g., G-protein signaling). Individual pathways are color-coded and cross-talk is indicated by solid lines. Signaling through all six pathways ultimately affects synaptic function by the regulation of ion channels and/or by altering transcription, thereby modulating learning and memory. Genes, protein products and their associated cognitive disorders as discussed in the text are shown.

AMPAR: AMPA receptor; ApoER2: ApoE receptor 2; CBP: CREB binding protein; Glu: Glutamate; NF1: Neurofibromatosis 1; NMDAR: N-methyl-D-aspartate receptor; Nt: Neurotransmitter; SR: Secretin receptor.