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. 2014 Jul 21;13:176. doi: 10.1186/1476-4598-13-176

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Copyright © 2014 Qian et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Signaling pathway of the proliferation is involved in KIF5B-RET positive cells. A & B. KIF5B-RET positively regulates the activation of the total STATs and ERK signaling pathways in positive cells. Control and enhanced KIF5B-RET expressing BEAS-2B (A) or A549 (B) cells were lysed and analyzed for phosphorylated Tyr⁷⁰⁵ STAT3 and Thr²⁰²/Tyr²⁰⁴ ERK_1/2 by western blots. C & D. The suppression of KIF5B-RET kinase activity by ZD6474 affects both STATs and ERK signaling pathways. Positive BEAS-2B or A549 cells were treated with ZD6474 at different doses for 48 h. Cells were lysed and analyzed by western blots for indicated marker antibodies. GAPDH was used as a loading control.