Table 1.
Demographic and clinical characteristics of study participants presenting with uncomplicated and severe malaria a
|
Characteristic |
UM
b
(n = 53) |
CM
c
(n = 44) |
SMA (n = 59) |
Pooled severe malaria |
|
|---|---|---|---|---|---|
| Survivors (n = 80) | Fatalities (n = 23) | ||||
|
Gender (% female) |
45.3 |
52.3 |
49.2 |
46.3 |
65.2§§ |
|
Age (years) |
4.4 (2.1, 8.1) |
3.0 (1.5, 4.3) |
1.3 (0.9, 2.0)***### |
1.6 (1.0, 3.1) |
1.9 (1.2, 3.3) |
|
Days reported ill prior to presentation |
3 (2, 4) |
3 (2, 4) |
4 (3, 5)***# |
3 (3, 4) |
3 (2, 7) |
|
Parasitaemia (parasites/μL) |
3.8 × 104 (1.6 × 104, 1.2 × 105) |
9.8 × 104 (1.5 × 104, 2.7 × 105) |
2.6 × 104 (7.4 × 103, 1.2 × 105)# |
3.7 × 104 (7.5 × 103, 1.5 × 105) |
1.6 × 105 (2.2 × 104, 3.9 × 105)§ |
| Fatal cases | 0 | 14 | 9 | 0 | 23 |
aTable reproduced from the previous study of this population (published in open access journal) [29]. Variables are presented as median (interquartile range). Groups were compared using the Mann Whitney U test or Kruskal-Wallis test with Dunn’s post-hoc tests (continuous variables) or Chi-square test (categorical variables). bUM, uncomplicated malaria; CM, cerebral malaria; SMA, severe malaria anaemia. c6 children with concurrent CM and SMA were included in the CM group. 5 children with SMA exhibited decreased consciousness but did not meet criteria for CM. *** p < 0.001 CM or SMA vs. UM. #p < 0.05, ###p < 0.001 SMA vs. CM. §p < 0.05, §§p < 0.01 fatalities vs. survivors.