Table 1.
Single-marker analyses between SNPs of KIAA0319 and categorical DD
| rs number | SNP | Position | Location | Reference allele (Frequency) | OR (95% CI) | Nominal p-value |
|---|---|---|---|---|---|---|
| rs2143340 |
C/T |
24659071 |
Intron 2 # (TDP2 gene) |
C (0.150) |
1.38 (0.86–2.23) |
0.1845 |
| rs9461045 |
C/T |
24649061 |
5′ Upstream |
C (0.346) |
0.83 (0.57–1.21) |
0.3400 |
| rs3756821 |
C/T |
24646821 |
5′ Upstream |
C (0.779) |
1.58 (1.01–2.48) |
0.0433* |
| rs2038137 |
G/T |
24645943 |
Intron 1 |
G (0.847) |
0.89 (0.51–1.54) |
0.6743 |
| rs2038139 |
A/C |
24645420 |
Intron 1 |
A (0.877) |
0.88 (0.49–1.57) |
0.6546 |
| rs9366577 |
C/T |
24641328 |
Intron 1 |
C (0.046) |
0.40 (0.16–1.03) |
0.0459* |
| rs730860 |
A/T |
24632427 |
Intron 1 |
A (0.284) |
0.95 (0.62–1.46) |
0.8273 |
| rs12194307 |
A/T |
24625562 |
Intron 1 |
A (0.896) |
0.86 (0.47–1.60) |
0.6393 |
| rs9467239 |
C/G |
24624857 |
Intron 1 |
C (0.398) |
0.98 (0.69–1.41) |
0.9270 |
| rs6915373 |
C/T |
24612902 |
Intron 1 |
C (0.540) |
0.90 (0.63–1.30) |
0.5806 |
| rs5026394 |
A/C |
24590547 |
Intron 3 |
A (0.583) |
1.13 (0.78–1.64) |
0.5101 |
| rs4504469 |
A/G |
24588884 |
Exon 4 |
A (0.129) |
1.11 (0.66–1.85) |
0.6961 |
| rs9295626 |
C/T |
24587339 |
Intron 4 |
C (0.756) |
1.09 (0.73–1.61) |
0.6861 |
| rs2760135 |
C/T |
24585547 |
Intron 4 |
C (0.438) |
1.15 (0.72–1.82) |
0.5583 |
| rs2817200 |
A/G |
24584366 |
Intron 4 |
A (0.774) |
0.79 (0.50–1.24) |
0.2981 |
| rs6901322 |
A/T |
24583804 |
Intron 5 |
Not in Hardy-Weinberg equilibrium (p < 0.1) |
||
| rs699461 |
A/G |
24582862 |
Intron 5 |
A (0.733) |
1.06 (0.72–1.56) |
0.7675 |
| rs807507 |
C/G |
24579867 |
Intron 8 |
C (0.215) |
1.15 (0.75–1.77) |
0.5125 |
| rs2760157 |
C/T |
24578272 |
Intron 9 |
C (0.486) |
0.98 (0.69–1.41) |
0.9276 |
| rs12213545 |
C/T |
24568452 |
Intron 13 |
C (0.900) |
1.10 (0.61–1.98) |
0.7630 |
| rs807540 |
C/T |
24559029 |
Intron 17 |
C (0.551) |
1.03 (0.72–1.48) |
0.9263 |
| rs9467220 |
C/T |
24550964 |
Intron 20 |
C (0.074) |
0.60 (0.29–1.23) |
0.1551 |
| rs10456306 |
C/T |
24550041 |
Intron 20 |
C (0.243) |
1.05 (0.69–1.59) |
0.8312 |
| rs807532 |
C/T |
24549668 |
Intron 20 |
C (0.467) |
0.95 (0.67–1.36) |
0.7868 |
| rs807530 | C/G | 24545939 | UTR-3 | C (0.782) | 1.13 (0.76–1.68) | 0.5443 |
*Adjusted p-value from permutation test is 0.5794. #This is the only SNP located in TDP2 gene. All the others are located in KIAA0319 gene.