Table 2.
Haplotype analyses of KIAA0319 region using 2- or 3-markers sliding windows in association with categorical DD
|
Haplotypes |
Frequency |
Global p-values |
Individual haplotype test |
Adjusted P value |
||
|---|---|---|---|---|---|---|
| OR (95% CI) | p-values | Permutation (1000) | ||||
| rs3756821- rs9366577 |
C-T |
0.791 |
0.0625 |
1 |
0.0495 |
|
| T-T |
0.168 |
0.5323 (0.1866 – 1.519) |
0.2568 |
|||
| T-C |
0.040 |
0.3874 (0.1499 – 1.001) |
0.0442 |
|||
| rs4504469 rs2038137 rs2143340 |
T-T-G |
0.668 |
0.3579 |
0.3703 (0.0906 – 1.513) |
0.4093 |
|
| T-T-C |
0.137 |
0.2569 (0.05752 – 1.148) |
0.1736 |
|
||
| A-G-G |
0.077 |
0.2598 (0.05393 – 1.251) |
0.3173 |
|
||
| C-G-G |
0.065 |
0.6415 (0.1436 – 2.866) |
0.2752 |
|
||
| A-C-G |
0.033 |
1 |
|
|
||
| A-G-C |
0.014 |
0.1851 (0.02041 – 1.68) |
0.4142 |
|
||
|
Sliding window |
|
|
|
|
|
|
|
2-markers |
|
|
|
|
|
|
| rs9366577- rs2038139 |
C-A |
0.041 |
0.0305 |
1 |
0.0116 |
0.3656 |
| T-A |
0.832 |
0.2667 (0.0885 – 0.8035) |
0.3173 |
|||
| T-C |
0.127 |
0.2333 (0.0669 – 0.8134) |
0.6547 |
|||
| rs6915373-rs9467239 |
C-C |
0.337 |
0.0375 |
1 |
0.3832 |
|
| C-G |
0.202 |
1.7480 (1.013 – 3.016) |
0.0528 |
|||
| T-C |
0.061 |
2.4560 (0.9815 – 6.145) |
0.0878 |
|||
| T-G |
0.401 |
0.9833 (0.6372 – 1.517) |
0.1215 |
|||
|
3-markers |
|
|
|
|
|
|
| rs9366577-rs2038139-rs2038137 |
C-A-G |
0.040 |
0.02347 |
5 (1.447 – 17.27) |
0.0047 |
0.3397 |
| T-A-G |
0.788 |
1 |
0.2041 |
|||
| T-A-T |
0.053 |
1.265 (0.4706 – 3.402) |
0.6171 |
|||
| T-C-T |
0.110 |
0.7706 (0.374 – 1.588) |
0.3692 |
|||
|
4-markers |
|
|
|
|
|
|
| rs9366577-rs2038139-rs208137- rs3756821 |
C-A-G-T |
0.041 |
0.0301 |
5.33 (1.535 – 18.53) |
0.0047 |
0.4306 |
| T-A-G-C |
0.635 |
1 |
0.0330 |
|||
| T-A-G-T |
0.156 |
1.654 (0.9109 – 3.005) |
0.1489 |
|||
| T-A-T-C |
0.042 |
1.809 (0.4949 – 6.614) |
0.5271 |
|||
| T-C-T-C | 0.109 | 0.859 (0.4114 – 1.793) | 0.3692 | |||