TABLE 1.
Reproductive history by cohort and endometriosis diagnosis, ENDO Study (n = 600)
| Characteristic | Operative cohort n = 473 |
Population cohort n = 127 |
||
|---|---|---|---|---|
| Endometriosis n = 190 n (%) |
No endometriosis n = 283 n (%) |
Endometriosis n = 14 n (%) |
No endometriosis n = 113 n (%) |
|
| Age, y | ||||
| <20 | 5 (2.6) | 7 (2.5) | 0 (0) | 4 (3.5) |
| 20–24 | 22 (11.6) | 26 (9.2) | 4 (28.6) | 21 (18.6) |
| 25–29 | 48 (25.3) | 55 (19.5) | 1 (7.1) | 22 (19.5) |
| 30–34 | 44 (23.2) | 58 (20.6) | 2 (14.3) | 18 (15.9) |
| ≥35 | 71 (37.4) | 136 (48.2) | 7 (50) | 48 (42.5) |
| Mean (SD) | 31.98 (6.75) | 33.61 (7.09)a | 33.14 (8.33) | 32.07 (7.76) |
| Ever sexually active | ||||
| No | 27 (14.2) | 37 (13.2) | 1 (7.1) | 14 (12.4) |
| Yes | 163 (85.8) | 244 (86.8) | 13 (92.9) | 99 (87.6) |
| Age at first consenting sex | ||||
| ≤17 | 92 (48.4) | 157 (55.5) | 4 (28.6) | 55 (48.7) |
| 18–20 | 50 (26.3) | 67 (23.7) | 6 (42.9) | 38 (33.6) |
| ≥21 | 48 (25.3) | 59 (20.8) | 4 (28.6) | 20 (17.7) |
| Mean (±SD) | 19.19 (4.28) | 18.33 (3.83) | 19.08 (2.47) | 18.49 (2.99) |
| Ever use oral contraceptives | ||||
| No | 21 (11.1) | 45 (15.9) | 1 (7.1) | 17 (15) |
| Yes | 169 (88.9) | 238 (84.1) | 13 (92.9) | 96 (85) |
| Gravidity | ||||
| Nulligravid (0) | 81 (42.6) | 74 (26.3)b | 5 (35.7) | 46 (40.7) |
| Gravid (≥1) | 109 (57.4) | 207 (73.7) | 9 (64.3) | 67 (59.3) |
| Mean (±SD) | 1.65 (1.98) | 2.28 (2.12)c | 2.21 (2.08) | 1.65 (1.80) |
| Parity (no. of live births) | ||||
| Nulliparous | 21 (19.4) | 25 (12.1) | 1 (11.1) | 10 (14.9) |
| Parous | 87 (80.6) | 182 (87.9) | 8 (88.9) | 57 (85.1) |
| Mean (±SD) | 1.81 (1.27) | 2.19 (1.44)d | 2.56 (1.59) | 2.21 (1.45) |
| Age at first pregnancy, y | ||||
| <20 | 42 (38.5) | 79 (38.2) | 0 (0) | 14 (20.9) |
| 20–24 | 42 (38.5) | 71 (34.3) | 5 (55.6) | 27 (40.3) |
| 25–29 | 20 (18.3) | 33 (15.9) | 4 (44.4) | 20 (29.9) |
| 30–34 | 4 (3.7) | 22 (10.6) | 0 (0) | 4 (6) |
| 35–39 | 1 (0.9) | 1 (0.5) | 0 (0) | 1 (1.5) |
| ≥40 | 0 (0) | 1 (0.5) | 0 (0) | 1 (1.5) |
| Mean (±SD) | 21.63 (4.19) | 21.98 (5.13) | 23.56 (2.79) | 23.64 (4.99) |
| History STIs | ||||
| No | 160 (84.2) | 219 (77.4) | 13 (92.9) | 91 (80.5) |
| Yes | 30 (15.8) | 64 (22.6) | 1 (7.1) | 22 (19.5) |
| History of abnormal pap smear | ||||
| No | 148 (77.9) | 210 (74.2) | 12 (85.7) | 80 (70.8) |
| Yes | 42 (22.1) | 73 (25.8) | 2 (14.3) | 33 (29.2) |
| Ever seek infertility treatment | ||||
| No | 126 (66.3) | 235 (83.0)e | 10 (71.4) | 107 (94.7)f |
| Yes | 64 (33.7) | 48 (17.0) | 4 (28.6) | 6 (5.3) |
| Surgical indication | ||||
| Pelvic pain | 120 (63.2) | 86 (30.5)g | ||
| Pelvic mass | 26 (13.7) | 48 (17.0) | ||
| Menstrual irregularity | 20 (10.5) | 40 (14.2) | ||
| Fibroids | 9 (4.7) | 40 (14.2) | ||
| Tubal ligation | 8 (4.2) | 40 (14.2) | ||
| Infertility | 7 (3.7) | 28 (9.9) | ||
Analysis excludes 22 women in operative cohort whose surgeries were cancelled, and 4 women in population cohort with unreadable magnetic resonance images.
STIs, sexually transmitted disease.
a
P = .0126;
b
P = .0002;
c
P = .0013;
d
P = .0191;
e
P = .00001;
f
P = .0023;
g
P = .0013.
Peterson. Risk factors associated with endometriosis. Am J Obstet Gynecol 2013.