Fig. 5.
Effects of prolonged continuous NACA treatment on hindlimb functional recovery following contusion SCI. Graphic representation of the mean behavioral (BBB) scores for rats treated with Vehicle, 150mg/kg NACA or 300mg/kg NACA following L1/L2 spinal cord injury. Compared to Vehicle-treated animals, 7 days of continuous NACA treatments resulted in improved hindlimb locomotor function after 42 days post-injury (DPI), when, both NACA- treated cohorts showed plantar stepping with weight-support with frequent to consistent coordination. Conversely, Vehicle-treated animals demonstrated primarily dorsal and occasional planter stepping. Symbols represent group means ± SEM, n=5–7/group. *p<0.05 Vehicle compared to 150mg/kg NACA and #p<0.05 Vehicle compared to 300mg/kg NACA.