Table 2.

Examples of genes/gene families mapped to the most representative core duplication

Duplicon clade	RefSeq gene	Gene name	Significant expression	Subcellular localization	Description	Possible function	Cancer association	Refs.
chr1	NM_183372	NBPF11	soft tissue	cytoplasm	neuroblastoma breakpoint gene family, DUF1220	unknown	neuroblastoma	1,2
chr2	NM_005054	RANBP2	testis	nuclear pore	RANBP2-like and GRIP domain-containing 5 isoform	Ran GTPase binding	highly expressed in leukemia	3
chr7_2	NM_174930	PMS2L5	ubiquitous	nuclear	postmeiotic segregation increased 2-like 5	DNA mismatch repair	unknown	4
chr15	NM_001012423	GLP	exclusively	unknown in testis	golgin-like protein, golgi autoantigen, golgin subfamily a, 8E (GOLGA8E)	DNA binding	unknown	5,6
chr16	NM_006985	NPIP	ubiquitous	nuclear membrane	nuclear pore complex interacting protein, morpheus gene family	Nuclear-pore- associated	highly expressed	7
chr17_1	NM_001006607	LRRC37B	ubiquitous	unknown	leucine-rich repeat, c114 SLIT-like testicular protein	ATP-dependent peptidase activity	unknown	8
chr17_2	NM_001001418	TBC1/USP6	testis	unknown	TBC1 domain family member 3C	GTPase activator activity	highly expressed in lymphoma	9

¹Laureys et al. (1990),

²Popescu et al. (2006),

³Ciccarelli et al. (2005),

⁴Horii et al. (1994),

⁵Pujana et al. (2002),

⁶Gilles et al. (2000),

⁷Johnson et al. (2001),

⁸Ota et al. (2004),

⁹Paulding et al. (2003).