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. 2014 Jun 30;6(1):12. doi: 10.1186/1868-7083-6-12

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Copyright © 2014 Modak et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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S. aureus infection induces mastitis in mice mammary tissue. (A) Comparative histopathological analysis of PBS (I) versus S. aureus (II and III) inoculated mice mammary tissue showed clear induction of mastitis after 24 h of infection. SA1 (panel II) inoculated tissue showed more pronounced infiltration of macrophages and neutrophils (blue arrow) in the alveolar lumen, than SA2 (panel III). Black arrow indicates tissue necrosis. (B,C) Temporal expression of various genes in infected tissue against PBS control was analyzed by qRT-PCR. Fold overexpression of the genes in S. aureus infected tissue over the control tissue was calculated and plotted as average of three biological replicates. SA1 (B) infection consistently showed higher inflammatory response compared to SA2 (C) at all time points.