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DVU0408 has PDE activity. HPLC traces for PDE activity assays with purified DVU0408 and 100 μM c-di-GMP in the presence of no metal (A); 2 mM MgCl2 (B); 2 mM MnCl2 (C,F); 2 mM MnCl2 and 100 μm GTP (D). Standards in (E) were a mix of 100 μm GTP, 100 μm GMP, and 100 μm c-di-GMP, while standards run in (G) were 100 μm pGpG alone. HPLC traces (F,G) were from separate runs than (A–E), and hence the slight shifting of the c-di-GMP and pGpG peaks.
