. 2014 Jul 29;5:378. doi: 10.3389/fmicb.2014.00378

Table 1.

Nomenclature, phenotype and in vivo functions of monocyte and DC subsets during MCMV infection.

Name	Markers	Functions during MCMV infection			References
		Infection^*	Innate immunity	Adaptive Immunity
XCR1⁺ cDC^**	Lin⁻ CD11b⁻ CD11c^high XCR1⁺ CD24⁺ CD8α^+/− CD103^+/−	Yes, <5%	IL-12, IL-15 … NK cell activation	Priming of antiviral CD8 T cells in acute infection	Andrews et al., 2003; Dalod et al., 2003; Torti et al., 2011b; Busche et al., 2013
CD11b⁺ cDC	Lin⁻ CD64⁻ MerTK⁻CD11c^high CD11b⁺	Yes, <<1%	IL-12, IL-15 … NK cell activation	Control of CD4 T cell priming?	Dalod et al., 2003; Andoniou et al., 2005
pDC	Lin⁻ CD11b⁻ CD11c^int Bst2⁺ SiglecH⁺	No	IFN-I, IL-12, TNF, CCL3 … NK cell activation	Dispensable?	Asselin-Paturel et al., 2001; Dalod et al., 2002, 2003; Krug et al., 2004; Scheu et al., 2008; Zucchini et al., 2008a; Swiecki et al., 2010
Classical monocytes/MDSC/MoDC^***	Lin⁻ MerTK⁻ CD11b⁺ Ly6C^high CCR2⁺ CD64^+/low	No	iNOS, TNF, IL-15? … recruitment in the liver	Dampening of CD8 T cell responses to prevent immunopathology?	Daley-Bauer et al., 2012; Livingston-Rosanoff et al., 2012
Non-classical monocytes	Lin⁻ MerTK⁻ Ly6C^−/low CD11b⁺ CX3CR1^high	Yes, dissemination of the virus, promotion of latent infection	?	?	Daley-Bauer et al., 2014
LC	Lin⁻ CD11c⁺ CD24⁺ CD11b⁺ CD207^high	No	?	?

In vivo viral infection of DC or monocyte subsets in mice challenged i.p. with MCMV.

^**

The name XCR1⁺ cDC is not yet an official nomenclature but has been coined here to define in a simple and general way all the CD8α⁺-type cDC of the mouse.

^***

Studies do not always rigorously discriminate between activated classical monocytes, myeloid-derived suppressor cells (MDSC) and MoDC, which are therefore discussed together here.

^?Contribution unknown.