Table 5.

Association of personality traits and lacunes, MTL atrophy, subcortical, and peripheral WML adjusted for age, sex, and education level.

Personality traits	Openness			Conscientiousness			Extraversion			Agreeableness			Neuroticism
	β (SE)	p	plinear	β (SE)	p	plinear	β (SE)	p	plinear	β (SE)	p	plinear	β (SE)	p	plinear
MTL atrophy
None or light	Ref		0.36	Ref		0.13	Ref		0.24	Ref		0.85	Ref		0.91
Mild	−0.24 (0.29)	0.42		0.34 (0.29)	0.25		0.26 (0.29)	0.38		−0.19 (0.29)	0.51		0.50 (0.29)	0.09
Moderate	0.45 (−0.29)	0.13		0.58 (0.29)	0.05		0.26 (0.29)	0.06		−0.01 (0.29)	0.98		0.13 (0.29)	0.64
Severe	−0.23 (0.40)	0.56		0.36 (0.40)	0.38		0.11 (0.40)	0.78		0.02 (0.40)	0.97		0.11 (0.40)	0.78
Subcortical WML
None	Ref		0.99	Ref		<0.01†	Ref		0.11	Ref		0.12	Ref		<0.01†
Light	−0.15 (0.26)	0.57		−0.46 (0.26)	0.07		−0.21 (0.26)	0.41		−0.16 (0.26)	0.54		0.54 (0.26)	0.04
Moderate or severe	−0.01 (0.29)	0.98		−0.81 (0.29)	0.006		−0.46 (0.29)	0.11		−0.44 (0.29)	0.13		0.72 (0.29)	0.01
Periventricular WML
None or light	Ref		0.90	Ref		0.10	Ref		0.72	Ref		0.26	Ref		0.09
Moderate	−0.06 (0.23)	0.78		−0.55 (0.23)	0.02		−0.06 (0.23)	0.79		−0.10 (0.23)	0.68		0.73 (0.23)	0.002
Severe	0.09 (0.31)	0.78		−0.29 (0.31)	0.37		−0.10 (0.31)	0.75		−0.38 (0.31)	0.23		0.19 (0.31)	0.55

Mixed model for repeated measure and random intercept adjusted for age, sex, and education level. MTL, medial temporal lobe; WML, white matter lesions.

*p < 0.05; ^†p < 0.01.