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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Cell. 2014 Jun 5;157(6):1339–1352. doi: 10.1016/j.cell.2014.05.012

Figure 3.

Figure 3

HIF-1α KO mice exhibit improved glucose tolerance and insulin sensitivity on HFD. (A) GTT with mice fed NCD. (B) GTT with mice fed HFD for 10 weeks. (C) Plasma insulin level during GTT in panel B. (D) ITT in mice fed HFD for 11 weeks. (E) Hyperinsulinemic euglycemic clamp performed on mice fed a HFD for 15 weeks. (F) Glucose uptake assays using primary adipocytes from WT or HAKO mice fed HFD for 15 weeks. All data represent mean+/-SEM. See also Figure S3.