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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Cell. 2014 Jun 5;157(6):1339–1352. doi: 10.1016/j.cell.2014.05.012

Figure 5.

Figure 5

HAKO mice fed a HFD show reduced NO production and Akt nitrosylation, and lower lactate production in adipocytes. (A) mRNA levels of iNOS and arginase 1 in adipocyte and eWAT SVCs from WT and HAKO mice. n=4 or 7 per group. (B) Nitrite level in eWAT of WT and HAKO mice. n=4 or 5 per group. (C) HFD-induced nitrosylation of Akt and total protein in adipose tissue is reduced by HAKO. (D) Akt phosphorylation in eWAT from WT or HAKO mice before and after insulin injection. (E) PDK expression. n=4 or 7 per group. (F) Fasting hepatic glucose production (HGP) is lower in HAKO mice on HFD. (G) Adipose tissue lactate content is decreased in HAKO mice. n=5 per group. All data represent mean+/-SEM.